Polish Mother’s Memorial Hospital - Research Institute in Łódź in cooperation with Biobank Lodz (University of Lodz) have published new paper about risk factors of breast cancer in Polish population. Results are presented in Clinical and Experimental Medicine. Enjoy your reading.

"New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients"

 

Hanna Romanowicz1, Dominik Strapagiel2, Marcin Słomka2, Marta Sobalska-Kwapis2, Ewa Kępka3, Anna Siewierska-Górska3, Marek Zadrożny4, Jan Bieńkiewicz5, Beata Smolarz1

    1.Laboratory of Cancer Genetics, Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital - Research Institute, Lodz, Poland
    2.Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
    3.Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
    4.Department of Oncological Surgery and Breast Diseases, Polish Mother’s Memorial Hospital - Research Institute, Lodz, Poland
    5.Department of Surgical, Endoscopic and Oncologic Gynaecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland

 
Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association between single nucleotide polymorphisms (SNPs) in homologous recombination repair genes and the incidence of breast cancer in the population of Polish women. Blood samples from 94 breast cancer patients were analysed as test group. Individuals were recruited into the study at the Department of Oncological Surgery and Breast Diseases of the Institute of the Polish Mother’s Memorial Hospital in Lodz, Poland. Healthy controls (n = 500) were obtained from the Biobank Laboratory, Department of Molecular Biophysics, University of Lodz. Then, DNA of breast cancer patients was compared with one of the disease-free women. The test was supported by microarray analysis. Statistically significant correlations were identified between breast cancer and 3 not described previously SNPs of homologous recombination repair genes BRCA1 and BRCA2: rs59004709, rs4986852 and rs1799950. Further studies on larger groups are warranted to support the hypothesis of correlation between the abovementioned genetic variants and breast cancer risk.

 

Funding resources:

POIG grant No. 01.01.02-10-005/08 TESTOPLEK from the European Regional Development Fund.

 

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